AAK1
AAK1 (AP2-associated kinase 1) is a founding member of the NAK family of clathrin-associated kinases. It binds the AP2 adaptor complex and phosphorylates the AP2 μ2 subunit, a modification that regulates cargo recognition and the dynamics of clathrin-mediated endocytosis. Structurally, AAK1 combines an N-terminal kinase domain with a central AP2-binding region and a C-terminal clathrin-binding segment, placing it directly on the endocytic coat machinery. Beyond endocytosis, AAK1 has been linked to neurite outgrowth, and host kinase screens identified it as a factor exploited by certain viruses for entry, raising its profile as a host-directed antiviral target. Small-molecule AAK1 inhibitors are under investigation. Recombinant AAK1 is used for endocytic-pathway and inhibitor studies.
-
AAK1 Recombinant Proteins (2)
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
