MAP3K14/NIK
MAP3K14, better known as NIK (NF-kappaB-inducing kinase), is the master regulator of the non-canonical NF-kappaB pathway. In resting cells NIK is continuously ubiquitinated and degraded by a TRAF3-cIAP1/2 complex; stimulation of receptors such as CD40, RANK, LTbetaR, and BAFF-R stabilizes the kinase, allowing it to phosphorylate IKKalpha, which then processes NF-kappaB2 p100 into p52 and activates RelB. NIK thereby controls lymphoid organogenesis, B-cell survival, osteoclast differentiation, and the formation of tertiary lymphoid structures in disease. Constitutive activation through TRAF3 loss occurs in multiple myeloma and certain lymphomas, positioning NIK as a therapeutic target in these hematologic malignancies and in autoimmune settings.
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MAP3K14/NIK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
