Calamistrins A and B, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Uvaria calamistrata
- J Nat Prod. 1999 Feb;62(2):261-4. doi: 10.1021/np980334q.
Affiliations
- 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
PMID: 10075755
DOI: 10.1021/np980334q
Abstract
Two new bioactive monotetrahydrofuran acetogenins, calamistrins A (1) and B (2), and two known compounds, uvarigrin (3) and uvarigranin (4), have been isolated from the roots of Uvaria calamistrata. The structures of the new compounds were elucidated by spectroscopic and chemical methods. The absolute stereochemistry of the stereogenic centers was established by Mosher ester methodology.