N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase

  • Bioorg Med Chem Lett. 1999 Apr 5;9(7):979-84. doi: 10.1016/s0960-894x(99)00117-1.
P J Connolly  1 ,  S K Wetter ,  K N Beers ,  S C Hamel ,  R H Chen ,  M P Wachter ,  J Ansell ,  M M Singer ,  M Steber ,  D M Ritchie ,  D C Argentieri
Affiliations
  • 1. The R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.
PMID: 10230624 DOI: 10.1016/s0960-894x(99)00117-1
Abstract

Two series of compounds (1 and 2) having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors; two compounds (1a and 2t) inhibit eicosanoid biosynthesis in an ex vivo assay.