Novel C-ring analogues of 20(S)-camptothecin. Part 3: synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues

  • Bioorg Med Chem Lett. 2000 Feb 21;10(4):369-71. doi: 10.1016/s0960-894x(00)00005-6.
D Subrahmanyam  1 ,  V M Sarma ,  A Venkateswarlu ,  T V Sastry ,  A S Srinivas ,  C V Krishna ,  D S Deevi ,  S A Kumar ,  M J Babu ,  N K Damodaran
Affiliations
  • 1. Natural Products Division, Dr. Reddy's Research Foundation, Hyderabad, AP, India. [email protected]
PMID: 10714502 DOI: 10.1016/s0960-894x(00)00005-6
Abstract

Several 5-substituted alkoxy 20(S)-camptothecin analogues having A- and B-ring substituents were prepared via semi-synthesis. Most of these compounds were found to exhibit potent anti-cancer activity based on their in vitro cytotoxicity data obtained against human tumor cell lines.