PF1163A and B, new antifungal antibiotics produced by Penicillium sp. II. Physico-chemical properties and structure elucidation

  • J Antibiot (Tokyo). 2000 Jan;53(1):38-44. doi: 10.7164/antibiotics.53.38.
T Sasaki  1 ,  H Nose ,  A Hosoya ,  S Yoshida ,  M Kawaguchi ,  T Watanabe ,  T Usui ,  Y Ohtsuka ,  T Shomura ,  S Takano ,  K Tatsuta
Affiliations
  • 1. Pharmaceutical Research Center, Meiji Seika, Ltd., Yokohama, Japan.
PMID: 10724006 DOI: 10.7164/antibiotics.53.38
Abstract

The structures of new antifungal Antibiotics, PF1163A and B, were elucidated by spectroscopic analyses of the degradation products and by X-ray crystallography of the de-2-hydroxyethyl derivative of PF1163B. Both Antibiotics consist of a 13-membered macrocyclic structure containing a derivative of N-methyl tyrosine and a hydroxy fatty acid. PF1163A differs from PF 1163B by having an additional hydroxyl group on the side chain.

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