Haematocin, a new antifungal diketopiperazine produced by Nectria haematococca Berk. et Br. (880701a-1) causing nectria blight disease on ornamental plants

  • J Antibiot (Tokyo). 2000 Jan;53(1):45-9. doi: 10.7164/antibiotics.53.45.
Y Suzuki  1 ,  H Takahashi ,  Y Esumi ,  T Arie ,  T Morita ,  H Koshino ,  J Uzawa ,  M Uramoto ,  I Yamaguchi
Affiliations
  • 1. The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama, Japan.
PMID: 10724007 DOI: 10.7164/antibiotics.53.45
Abstract

A new Antifungal diketopiperazine named haematocin was isolated from the culture broth of Nectria haematococca Berk. et Br. (880701a-1) causing blight disease on ornamental Plants, Phalaenopsis spp. and Doritanopsis spp. Its structure was established by spectroscopic methods. Haematocin inhibited the germ-tube elongation and spore-germination of Pyricularia oryzae at the ED50 values of 30 microg/ml and 160 microg/ml, respectively.

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