Triterpenoids from Tripterygium wilfordii

  • Phytochemistry. 2000 Apr;53(7):805-10. doi: 10.1016/s0031-9422(00)00007-8.
H Duan  1 ,  Y Takaishi ,  H Momota ,  Y Ohmoto ,  T Taki ,  Y Jia ,  D Li
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
PMID: 10783986 DOI: 10.1016/s0031-9422(00)00007-8
Abstract

The extract (T(II)) of Tripterygium wilfordii Hook f. afforded four triterpenoids: wilforic acid D (3beta,24-epoxy-2alpha-hydroxy-24R*-ethoxy-29-friedelanoic acid); (E) 3beta,24-epoxy-2-oxo-3alpha-hydroxy-29-friedelanoic acid; (F) 2beta-hydroxy-3-oxo-friedelan-29-oic acid; 29-hydroxy-3-oxo-olean-12-en-28-oic acid and 17 known triterpenoids. Their structures were established on the basis of spectroscopic studies. In a bioactivity analysis, only the known dulcioic acid compound showed a significant inhibitory effect on cytokine production.

Products