Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activities

  • J Antibiot (Tokyo). 2000 Aug;53(8):779-87. doi: 10.7164/antibiotics.53.779.
J Schimana  1 ,  H P Fiedler ,  I Groth ,  R Süssmuth ,  W Beil ,  M Walker ,  A Zeeck
Affiliations
  • 1. Mikrobiologisches Institut, Universität Tübingen, Germany.
PMID: 11079799 DOI: 10.7164/antibiotics.53.779
Abstract

Two novel angucyclinone-type Antibiotics, simocyclinones D4 and D8, were detected in the mycelium Extract of Streptomyces antibioticus Tü 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show Antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.

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