Augmented death in immunostimulated astrocytes deprived of glucose: inhibition by an iron porphyrin FeTMPyP

  • J Neuroimmunol. 2001 Jan 1;112(1-2):55-62. doi: 10.1016/s0165-5728(00)00382-9.
I Y Choi  1 ,  S J Lee ,  W Nam ,  J S Park ,  K H Ko ,  H C Kim ,  C Y Shin ,  J H Chung ,  S K Noh ,  C R Choi ,  D H Shin ,  W K Kim
Affiliations
  • 1. Department of Chemistry and Division of Molecular Life Sciences, Seoul, South Korea.
PMID: 11108933 DOI: 10.1016/s0165-5728(00)00382-9
Abstract

The present study shows that under glucose-deprived conditions immunostimulated astrocytes rapidly undergo death due to their increased susceptibility to endogenously produced peroxynitrite. Fe(III)tetrakis(N-methyl-4'-pyridyl)porphyrin (FeTMPyP), but not the structurally related compounds ZnTMPyP and H(2)TMPyP, prevented the death in glucose-deprived immunostimulated astrocytes. Consistently, FeTMPyP, not ZnTMPyP and H(2)TMPyP, completely blocked the elevation of nitrotyrosine immunoreactivity (a marker of peroxynitrite) and the depolarization of the mitochondrial transmembrane potential in glucose-deprived immunostimulated astrocytes. The present data suggest that peroxynitrite may be associated with glial cell death during metabolic deterioration in the cerebral ischemic penumbra.

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