Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids

  • Bioorg Med Chem Lett. 2001 Mar 26;11(6):811-4. doi: 10.1016/s0960-894x(01)00067-1.
M D Wittman  1 ,  J F Kadow ,  D M Vyas ,  F L Lee ,  W C Rose ,  B H Long ,  C Fairchild ,  K Johnston
Affiliations
  • 1. Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA. [email protected]
PMID: 11277526 DOI: 10.1016/s0960-894x(01)00067-1
Abstract

The syntheses and antitumor activity of three paclitaxel-chlorambucil hybrids are presented. Hybrid 3 showed significant in vivo efficacy.