New taxane analogues from the needles of Taxus canadensis

  • J Nat Prod. 2001 Apr;64(4):450-5. doi: 10.1021/np0004449.
J Zhang  1 ,  F Sauriol ,  O Mamer ,  X L You ,  M A Alaoui-Jamali ,  G Batist ,  L O Zamir
Affiliations
  • 1. Human Health Research Center, INRS-Institut Armand-Frappier, Université du Québec, 531 Boulevard des Prairies, Laval, Québec, Canada, H7V 1 B7.
PMID: 11325226 DOI: 10.1021/np0004449
Abstract

Eight minor taxanes have been identified for the first time in Taxus canadensis needles. Four of these metabolites are new taxane analogues: 7-acetyl-10-deacetyltaxol (1), 2'-acetyl-7-epi-cephalomannine (2), 10-deacetyl-10-oxo-7-epi-cephalomannine (3), and 10-acetylglycollylbaccatin VI (4).