Dendocarbins A--N, new drimane sesquiterpenes from the nudibranch Dendrodoris carbunculosa

  • J Nat Prod. 2001 Jun;64(6):726-31. doi: 10.1021/np000639g.
Y Sakio  1 ,  Y J Hirano ,  M Hayashi ,  K Komiyama ,  M Ishibashi
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
PMID: 11421732 DOI: 10.1021/np000639g
Abstract

Fourteen new Sesquiterpenes of the drimane series dendocarbins A--N (1--14) were obtained from ethanol extracts of the Japanese nudibranch Dendrodoris carbunculosa, together with two known compounds, isodrimeninol (15) and 11-epivaldiviolide (16). All structures were elucidated mainly from spectral data, and most of these Sesquiterpenes were found to exhibit cytotoxicity. In addition, isodrimeninol (15), the major sesquiterpene of this animal, was found to have a sharp peppery taste.