Synthesis and biological activity of the new 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid

  • Bioorg Med Chem Lett. 2002 Feb 11;12(3):483-6. doi: 10.1016/s0960-894x(01)00782-x.
Kwan-Hee Kim  1 ,  Ji-Young Kim ,  Keyong-Ho Lee ,  Moon-Jong Noh ,  Youn-Chul Kim ,  Ho-Jin Park
Affiliations
  • 1. Biomedical Research Institute, Kolon Central Research Park, 207-2Mabuk-Ri, Guseong-Eup, Yongin-City, Kyunggi-Do 449-797, Republic of Korea. [email protected]
PMID: 11814824 DOI: 10.1016/s0960-894x(01)00782-x
Abstract

A series of 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid 6, were synthesized and evaluated for their antitumor activity.