One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization

  • J Med Chem. 2002 Jun 6;45(12):2670-3. doi: 10.1021/jm020077t.
Bernard L Flynn  1 ,  Ernest Hamel ,  M Katherine Jung
Affiliations
  • 1. Department of Chemistry, The Faculties, Australian National University, Canberra, ACT 0200, Australia. [email protected]
PMID: 12036378 DOI: 10.1021/jm020077t
Abstract

Benzo[b]furan and indole analogues of some recently identified benzo[b]thiophene inhibitors of tubulin polymerization have been prepared, and their biological activity has been assessed. Several very potent analogues were identified.