Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase

  • Bioorg Med Chem Lett. 2002 Aug 19;12(16):2137-40. doi: 10.1016/s0960-894x(02)00351-7.
William J Pitts  1 ,  Junqing Guo ,  T G Murali Dhar ,  Zhongqi Shen ,  Henry H Gu ,  Scott H Watterson ,  Mark S Bednarz ,  Bang Chi Chen ,  Joel C Barrish ,  Donna Bassolino ,  Daniel Cheney ,  Catherine A Fleener ,  Katherine A Rouleau ,  Diane L Hollenbaugh ,  Edwin J Iwanowicz
Affiliations
  • 1. Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 12127522 DOI: 10.1016/s0960-894x(02)00351-7
Abstract

A series of novel triazine-based small molecule inhibitors (IV) of Inosine monophosphate dehydrogenase was prepared. The synthesis and the structure-activity relationships (SAR) derived from in vitro studies are described.