New alkaloids of the sarpagine group from Rauvolfia serpentina hairy root culture

  • J Nat Prod. 2002 Jul;65(7):1006-10. doi: 10.1021/np0200919.
Yuri Sheludko  1 ,  Irina Gerasimenko ,  Heinz Kolshorn ,  Joachim Stöckigt
Affiliations
  • 1. Department of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg-University, Staudinger Weg 5, D-55099 Mainz, Germany.
PMID: 12141861 DOI: 10.1021/np0200919
Abstract

Three new monoterpenoid Indole Alkaloids, 19(S),20(R)-dihydroperaksine (1), 19(S),20(R)-dihydroperaksine-17-al (2), and 10-hydroxy-19(S),20(R)-dihydroperaksine (3), along with 16 known Alkaloids 4-19 were isolated from hairy root culture of Rauvolfia serpentina, and their structures were elucidated by 1D and 2D NMR analyses. Taking into account the stereochemistry of the new Alkaloids and results of preliminary enzymatical studies, the putative biosynthetical relationships between the novel Alkaloids are discussed.

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