Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase

  • Bioorg Med Chem Lett. 2002 Oct 21;12(20):2879-82. doi: 10.1016/s0960-894x(02)00601-7.
Scott H Watterson  1 ,  Chunjian Liu ,  T G Murali Dhar ,  Henry H Gu ,  William J Pitts ,  Joel C Barrish ,  Catherine A Fleener ,  Katherine Rouleau ,  N Z Sherbina ,  Diane L Hollenbaugh ,  Edwin J Iwanowicz
Affiliations
  • 1. Bristol-Myers Squibb PRI, PO Box 4000, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 12270168 DOI: 10.1016/s0960-894x(02)00601-7
Abstract

A series of novel amide-based small molecule inhibitors of Inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.