Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents

  • Bioorg Med Chem Lett. 2003 Jan 6;13(1):101-5. doi: 10.1016/s0960-894x(02)00850-8.
Hsing-Pang Hsieh  1 ,  Jing-Ping Liou ,  Ying-Ting Lin ,  Neeraj Mahindroo ,  Jang-Yang Chang ,  Yung-Ning Yang ,  Shuenn-Shing Chern ,  Uan-Kang Tan ,  Chun-Wei Chang ,  Tung-Wei Chen ,  Chi-Hung Lin ,  Ying-Ying Chang ,  Chiung-Chiu Wang
Affiliations
  • 1. Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 9F, 161, Sec. 6, Min-Chiuan East Road, Taipei 114, Taiwan, ROC. [email protected]
PMID: 12467626 DOI: 10.1016/s0960-894x(02)00850-8
Abstract

Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human Cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.