Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series

  • Bioorg Med Chem Lett. 2003 Feb 10;13(3):543-6. doi: 10.1016/s0960-894x(02)00944-7.
Scott H Watterson  1 ,  Marianne Carlsen ,  T G Murali Dhar ,  Zhongqi Shen ,  William J Pitts ,  Junqing Guo ,  Henry H Gu ,  Derek Norris ,  John Chorba ,  Ping Chen ,  Daniel Cheney ,  Mark Witmer ,  Catherine A Fleener ,  Katherine Rouleau ,  Robert Townsend ,  Diane L Hollenbaugh ,  Edwin J Iwanowicz
Affiliations
  • 1. Bristol-Myers Squibb PRI, PO Box 400, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 12565968 DOI: 10.1016/s0960-894x(02)00944-7
Abstract

A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.