Monoamine oxidases: to inhibit or not to inhibit

  • Mini Rev Med Chem. 2003 Mar;3(2):129-36. doi: 10.2174/1389557033405287.
R R Ramsay  1 ,  M B Gravestock
Affiliations
  • 1. Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland, UK. [email protected]
PMID: 12570845 DOI: 10.2174/1389557033405287
Abstract

Monoamine Oxidase (MAO) inhibitors were developed as antidepressants but many drugs, including the novel oxazolidinone Antibacterial agents, share similar molecular properties and have MAO inhibitory activity. Factors important for binding antidepressants and modifications to decrease binding of oxazolidinones to avoid undesirable vascular effects are discussed.

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