Reaction of irofulven with zinc and acid

  • J Nat Prod. 2003 Feb;66(2):310-2. doi: 10.1021/np0204085.
Trevor C McMorris  1 ,  Surk-Sik Moon ,  Michael J Kelner
Affiliations
  • 1. Department of Chemistry, University of California, San Diego, La Jolla, California 92093-0506, USA. [email protected]
PMID: 12608875 DOI: 10.1021/np0204085
Abstract

Reaction of antitumor agent irofulven (1) with zinc and acetic acid yielded several new indene derivatives (6, 7, 8, 10) as well as the known indene (9). These all have greatly reduced toxicity to human leukemia (HL60) cells compared to irofulven.