Inhibition of prolyl endopeptidase by synthetic peptide fragments of human beta-casein

  • Agric Biol Chem. 1991 Mar;55(3):825-8.
M Asano  1 ,  N Nio ,  Y Ariyoshi
Affiliations
  • 1. Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
PMID: 1368631
Abstract

It has been suggested that peptide inhibitors of prolyl endopeptidase (PEP) may act as anti-amnestic agents. In the hope of finding PEP inhibitors in milk proteins, we synthesized a total of 37 human beta-casein peptide fragments containing proline residues. It was found that the peptides with PEP inhibition activity in vitro were located in the region of amino acid residues 49-59 of human beta-casein. The most potent inhibitor was Ile-Tyr-Pro-Phe-Val-Glu-Pro-Ile (IC50 = 8 microM).

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