Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. II. Structure determination of benastatins A and B

  • J Antibiot (Tokyo). 1992 Sep;45(9):1391-6. doi: 10.7164/antibiotics.45.1391.
T Aoyama  1 ,  H Naganawa ,  Y Muraoka ,  H Nakamura ,  T Aoyagi ,  T Takeuchi ,  Y Iitaka
Affiliations
  • 1. Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 1429223 DOI: 10.7164/antibiotics.45.1391
Abstract

Benastatins A and B, new inhibitors of Glutathione S-transferase, have been isolated from the culture broth of Streptomyces sp. MI384-DF12. By X-ray crystallography, benastatin A was determined to be 8,13-dihydro-1,7,9,11-tetrahydroxy-13-dimethyl-8-oxo-3-pentyl- benzo[a]naphthacene-2-carboxylic acid. The structure of benastatin B was elucidated by NMR studies.

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