Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at the 7-, 10- and 20-positions

  • Bioorg Med Chem Lett. 2003 Nov 3;13(21):3739-41. doi: 10.1016/j.bmcl.2003.08.012.
Xian-dao Pan  1 ,  Rui Han ,  Piao-yang Sun
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. [email protected]
PMID: 14552770 DOI: 10.1016/j.bmcl.2003.08.012
Abstract

A series of 7-acyloxymethylcamptothecin and 20-O-acyl-7-acyloxymethylcamptothecin derivatives were regioselectively prepared on different Solvents. 7-Acyloxymethylcamptothecins possess more efficacy than 20-O-acyl-7-acyloxymethylcamptothecins against six human Cancer cell lines in vitro.