Anti-tumor activities of decursinol angelate and decursin from Angelica gigas

  • Arch Pharm Res. 2003 Sep;26(9):727-30. doi: 10.1007/BF02976682.
Sanghyun Lee  1 ,  Yeon Sil Lee ,  Sang Hoon Jung ,  Kuk Hyun Shin ,  Bak-Kwang Kim ,  Sam Sik Kang
Affiliations
  • 1. Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea.
PMID: 14560921 DOI: 10.1007/BF02976682
Abstract

The in vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots of Angelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume of mice inoculated with Sarcoma-180 tumor cells. These results suggest that decursinol angelate (1) and decursin (2) from A. gigas have anti-tumor activities.

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