7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases

  • J Med Chem. 2004 Mar 25;47(7):1599-601. doi: 10.1021/jm0499458.
Diane H Boschelli  1 ,  Yanong D Wang ,  Steve Johnson ,  Biqi Wu ,  Fei Ye ,  Ana Carolina Barrios Sosa ,  Jennifer M Golas ,  Frank Boschelli
Affiliations
  • 1. Chemical and Screening Sciences and Oncology, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. [email protected]
PMID: 15027848 DOI: 10.1021/jm0499458
Abstract

We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.