Biaryl amide glucagon receptor antagonists

  • Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50. doi: 10.1016/j.bmcl.2004.02.056.
Ravi Kurukulasuriya  1 ,  Bryan K Sorensen ,  James T Link ,  Jyoti R Patel ,  Hwan-Soo Jae ,  Marty X Winn ,  Jeffrey R Rohde ,  Nelson D Grihalde ,  Chun W Lin ,  Christopher A Ogiela ,  Andrew L Adler ,  Christine A Collins
Affiliations
  • 1. Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. [email protected]
PMID: 15080976 DOI: 10.1016/j.bmcl.2004.02.056
Abstract

Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human Glucagon Receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge.

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