Synthesis of analogues of a potent antitumor saponin OSW-1

  • Bioorg Med Chem Lett. 2004 Jun 21;14(12):3323-6. doi: 10.1016/j.bmcl.2004.03.102.
Jacek W Morzycki  1 ,  Agnieszka Wojtkielewicz ,  Sławomir Wołczyński
Affiliations
  • 1. Institute of Chemistry, University of Bialystok, al. Pilsudskiego 11/4, 15-443 Bialystok, Poland. [email protected]
PMID: 15149699 DOI: 10.1016/j.bmcl.2004.03.102
Abstract

A series of side chain analogues (5a-e), a 22-glycosylated isomer (10), and 16beta-O-l-arabinosyl (13a) or 16beta-O-d-xylosyl (13b) analogues of OSW-1 were synthesized. All analogues were found to be less cytotoxic against breast and endometrial Cancer cell lines than the natural product.