Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents

  • Bioorg Med Chem Lett. 2004 Jul 5;14(13):3517-20. doi: 10.1016/j.bmcl.2004.04.067.
Kenneth L Smith  1 ,  Vicky C H Lai ,  Brett J Prigaro ,  Yili Ding ,  Esmir Gunic ,  Jean-Luc Girardet ,  Weidong Zhong ,  Zhi Hong ,  Stanley Lang ,  Haoyun An
Affiliations
  • 1. Valeant Pharmaceuticals International, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA.
PMID: 15177464 DOI: 10.1016/j.bmcl.2004.04.067
Abstract

Ten new beta-D-ribofuranosyl and 2'-beta-C-methyl-beta-D-ribofuranosyl triciribine derivatives 4-13 with various N4 and 6-N substituents on the tricyclic ring were synthesized from the corresponding toyocamycin and new 2'-beta-C-methyl toyocamycin derivatives. The inhibitory studies of these compounds in the HCV replicon assay reveal that some of them possess interesting anti-HCV properties with low cytotoxicity.