Antitumor agents. 233. Lantalucratins A-F, new cytotoxic naphthoquinones from Lantana involucrata

  • J Nat Prod. 2004 Jun;67(6):990-3. doi: 10.1021/np030450f.
Ken-ichiro Hayashi  1 ,  Fang-Rong Chang ,  Yuka Nakanishi ,  Kenneth F Bastow ,  Gordon Cragg ,  Andrew T McPhail ,  Hiroshi Nozaki ,  Kuo-Hsiung Lee
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
PMID: 15217280 DOI: 10.1021/np030450f
Abstract

In a continuing study to isolate novel antitumor agents from rainforest Plants, three new isopropenylfurano-beta-naphthoquinones, designated lantalucratins A (1), B (2), and C (3), and three new isoprenyl-alpha-naphthoquinones, designated lantalucratins D (4), E (5), and F (6), were isolated from Lantana involucrata. Their structures were determined on the basis of NMR and X-ray crystallographic analyses. Compounds 1 and 2 showed cytotoxic activities against various human tumor cell lines, including drug-resistant variants, with IC50 values of 1.0-4.9 microM.