Pulsatilla saponin D: the antitumor principle from Pulsatilla koreana

  • Arch Pharm Res. 2004 Sep;27(9):915-8. doi: 10.1007/BF02975843.
Yong Kim  1 ,  Seong-Cheol Bang ,  Ji-Hyun Lee ,  Byung-Zun Ahn
Affiliations
  • 1. SB Pharmaceutical Co. LTD, 533-2 Bonggok-ri, Banpo-myeon, Gongju-shi 314-923, Chungnam, Korea.
PMID: 15473660 DOI: 10.1007/BF02975843
Abstract

By bioassay-guided separation, an already known saponin, Pulsatilla saponin D was isolated from the root of Pulsatilla koreana Nakai as a antitumor component when evaluated by in vivo antitumor activity as well as in vitro cytotoxic activity test. It showed potent inhibition rate of tumor growth (IR, 82%) at the dose of 6.4 mg/kg on the BDF1 mice bearing LLC cells.

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