Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives

  • Bioorg Med Chem Lett. 2005 Jan 17;15(2):267-9. doi: 10.1016/j.bmcl.2004.10.087.
Jun Cheng  1 ,  Jiangtao Xie ,  Xianjin Luo
Affiliations
  • 1. School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240, PR China.
PMID: 15603937 DOI: 10.1016/j.bmcl.2004.10.087
Abstract

Some benzimidazole derivatives were synthesized and evaluated for their Antiviral properties. Compounds 20 and 21 showed potent selective activity against Coxsackie virus B(3) in VERO cells. Some structure-activity relationships were discussed.