Cytotoxic flavanones of Schizolaena hystrix from the Madagascar rainforest

  • J Nat Prod. 2005 Mar;68(3):417-9. doi: 10.1021/np049639x.
Brian T Murphy  1 ,  Shugeng Cao ,  Andrew Norris ,  James S Miller ,  Fidisoa Ratovoson ,  Rabodo Andriantsiferana ,  Vincent E Rasamison ,  David G I Kingston
Affiliations
  • 1. Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0212, USA.
PMID: 15787448 DOI: 10.1021/np049639x
Abstract

Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of Schizolaena hystrix afforded three new flavanones, schizolaenone A (1), schizolaenone B (2), and 4'-O-methylbonannione A (3), as well as three known flavanones, nymphaeol A, bonannione A, and macarangaflavanone B, and the flavanol bonanniol A. The structures of compounds 1-3 were determined by various one- and two-dimensional NMR techniques. All of the isolates were tested for cytotoxicity against the A2780 human ovarian Cancer cell line. Nymphaeol A (IC(50) = 5.5 microg/mL) exhibited the greatest cytotoxicity, while the Other flavanones were found to be only weakly active.