Identification of antitumor activity of pyrazole oxime ethers

  • Bioorg Med Chem Lett. 2005 Jul 1;15(13):3307-12. doi: 10.1016/j.bmcl.2005.03.082.
Hyun-Ja Park  1 ,  Kyung Lee ,  Su-Jin Park ,  Bangle Ahn ,  Jong-Cheol Lee ,  Heeyeong Cho ,  Kee-In Lee
Affiliations
  • 1. Bio-Organic Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305-600, Republic of Korea.
PMID: 15922597 DOI: 10.1016/j.bmcl.2005.03.082
Abstract

A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.