Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors

  • Bioorg Med Chem Lett. 2005 Aug 1;15(15):3560-4. doi: 10.1016/j.bmcl.2005.05.101.
Ronald G Sherrill  1 ,  Eric S Furfine ,  Richard J Hazen ,  John F Miller ,  David J Reynolds ,  Douglas M Sammond ,  Andrew Spaltenstein ,  Pat Wheelan ,  Lois L Wright
Affiliations
  • 1. GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. [email protected]
PMID: 15975788 DOI: 10.1016/j.bmcl.2005.05.101
Abstract

A series of novel N-alkoxy-arylsulfonamide HIV Protease Inhibitors with low picomolar enzyme activity and single digit nanomolar Antiviral activity is disclosed.