Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol

  • Bioorg Med Chem Lett. 2005 Aug 1;15(15):3580-3. doi: 10.1016/j.bmcl.2005.05.065.
Byeong-Seon Jeong  1 ,  Nam Song Choi ,  Soon Kil Ahn ,  Hoon Bae ,  Hak Sung Kim ,  Deukjoon Kim
Affiliations
  • 1. New Drug Research Laboratories, Chong Kun Dang Research Institute, Cheonan 330-831, Republic of Korea.
PMID: 15978809 DOI: 10.1016/j.bmcl.2005.05.065
Abstract

Novel cyclopentane analogues of fumagillol were synthesized and their endothelial cell proliferation inhibitory activities were evaluated. The cyclopentane-fumagillol derivatives were synthesized from (-)-2,3-O-isopropylidene-D-erythronolactone via stereoselective glycolate Claisen rearrangement and intramolecular ester enolate alkylation as key steps.