Interaction of chiral MS-245 analogs at h5-HT6 receptors

  • Bioorg Med Chem Lett. 2005 Aug 1;15(15):3510-3. doi: 10.1016/j.bmcl.2005.05.092.
Carmen Abate  1 ,  Renata Kolanos ,  Malgorzata Dukat ,  Vince Setola ,  Bryan L Roth ,  Richard A Glennon
Affiliations
  • 1. Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
PMID: 15990303 DOI: 10.1016/j.bmcl.2005.05.092
Abstract

Optically active pyrrolidinylmethylindole analogs related in structure to the benzenesulfonyltryptamine 5-HT(6) receptor antagonist MS-245 were evaluated and their R-isomers were found to bind with affinity higher than their S-enantiomers.

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