Synthesis of some new 2-(6-methoxy-2-naphthyl)- 5-aryl-1,3,4-oxadiazoles as possible non-steroidal anti-inflammatory and analgesic agents

  • Arch Pharm (Weinheim). 2005 Aug;338(8):373-7. doi: 10.1002/ardp.200500974.
Badiadka Narayana  1 ,  Kuniyil Kulangara Vijaya Raj ,  Badiadka Valamale Ashalatha ,  Nalilu Suchetha Kumari
Affiliations
  • 1. Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangotri, India. [email protected]
PMID: 16041838 DOI: 10.1002/ardp.200500974
Abstract

The synthesis of some new 2-(6-methoxy-2-naphthyl)-5-aryl-1,3,4-oxadiazoles (4a-k) has been described. Ethyl-6-methoxy-2-naphthoate (1) yielded on treatment with hydrazine hydrate to 6-methoxy-2-naphthoic acid hydrazide (2). Compound 2 reacted with substituted aromatic carboxylic acids (3a-k) in phosphorus oxychloride yielded 2-(6-methoxy-2-naphthyl)-5-aryl-1,3,4-oxadiazoles (4a-k). Newly synthesized compounds were characterized by IR, (1)H-NMR and mass spectral data. All the compounds were screened for their anti-inflammatory and analgesic activity. Compound 4j exhibited promising anti-inflammatory and analgesic activities.

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