Lignans from bark of Larix olgensis var. koreana

  • J Nat Prod. 2005 Aug;68(8):1175-9. doi: 10.1021/np058022s.
Bao-Hua Yang  1 ,  Wei-Dong Zhang ,  Run-Hui Liu ,  Ting-Zhao Li ,  Chuan Zhang ,  Yun Zhou ,  Juan Su
Affiliations
  • 1. Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
PMID: 16124756 DOI: 10.1021/np058022s
Abstract

Six new Lignans (2-7) were isolated from the bark of Larix olgensis var. koreana, and their structures were determined on the basis of their spectroscopic data. Seven known Lignans were also obtained and identified as (+)-lariciresinol 9'-p-coumarate (1), (+)-lariciresinol, (-)-secoisolariciresinol, (+)-isolariciresinol, vladinol D, sesquipinsapol B, and ehletianol C. Compound 1 showed weak inhibition against K562, SHG44, HCT-8, A549, and PC-3M tumor cells with IC50 values of 2.9, 21.4, 32.9, 33.8, and 28.0 microg/mL, respectively.

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