A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

  • Bioorg Med Chem Lett. 2006 Feb;16(3):718-21. doi: 10.1016/j.bmcl.2005.10.026.
Robert J Chambers  1 ,  Kristin Abrams ,  Tessa A Castleberry ,  John B Cheng ,  Douglas A Fisher ,  Ajith V Kamath ,  Anthony Marfat ,  David O Nettleton ,  Joann D Pillar ,  Eben D Salter ,  Alissa L Sheils ,  John T Shirley ,  Claudia R Turner ,  John P Umland ,  Kelvin T Lam
Affiliations
  • 1. Groton Laboratories, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. [email protected]
PMID: 16263279 DOI: 10.1016/j.bmcl.2005.10.026
Abstract

Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.