Indoloprodigiosins from the C-10 bipyrrolic precursor: new antiproliferative prodigiosin analogs
- Bioorg Med Chem Lett. 2006 Feb;16(3):701-4. doi: 10.1016/j.bmcl.2005.10.027.
Affiliations
- 1. ArQule Inc. 19 Presidential Way, Woburn, MA 01801-5140, USA. [email protected]
PMID: 16289814
DOI: 10.1016/j.bmcl.2005.10.027
Abstract
The condensation of the C-10 methoxybipyrrole precursor (3) of prodigiosin with indoles and a related pyrrole derivative yields novel analogs of prodigiosin. Biological evaluation of these products revealed compounds that inhibit Cancer cell proliferation from 50 nM to 50 microM.