Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2

  • Bioorg Med Chem Lett. 2006 Mar 15;16(6):1696-701. doi: 10.1016/j.bmcl.2005.12.006.
Xiaoyan Zhang  1 ,  Maud Urbanski ,  Mona Patel ,  Geoffrey G Cox ,  Roxanne E Zeck ,  Haiyan Bian ,  Bruce R Conway ,  Mary Pat Beavers ,  Philip J Rybczynski ,  Keith T Demarest
Affiliations
  • 1. Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA. [email protected]
PMID: 16380256 DOI: 10.1016/j.bmcl.2005.12.006
Abstract

A series of indole-O-glucosides and C-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats.