Isoflavonoids with antiestrogenic activity from Millettia pachycarpa

  • J Nat Prod. 2006 Jan;69(1):138-41. doi: 10.1021/np050341w.
Chihiro Ito  1 ,  Masataka Itoigawa ,  Minako Kumagaya ,  Yoshinori Okamoto ,  Koji Ueda ,  Tsutomu Nishihara ,  Nakao Kojima ,  Hiroshi Furukawa
Affiliations
  • 1. Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
PMID: 16441086 DOI: 10.1021/np050341w
Abstract

Three new isoflavonoids, named millewanins G (1) and H (2) and furowanin B (3), were isolated from the leaves of Millettia pachycarpa. Their structures were elucidated on the basis of spectroscopic analyses. The antiestrogenic activity in the yeast two-hybrid assay of these isoflavonoids was examined and shown to be comparable with that of 4-hydroxytamoxifen.

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