A new neuroprotective compound of Ligustrum japonicum leaves

  • Planta Med. 2006 Jan;72(1):62-4. doi: 10.1055/s-2005-873140.
Sang Hyun Sung  1 ,  Eun Sil Kim ,  Ki Yong Lee ,  Mi Kyeong Lee ,  Young Choong Kim
Affiliations
  • 1. Elcom Science Co., Ltd., Seoul, Korea.
PMID: 16450298 DOI: 10.1055/s-2005-873140
Abstract

A new secoiridoid glycoside characterized as (8 Z)-nuezhenide A along with five known glycosides, (8 E)-nuezhenide, (8 Z)-nuezhenide, oleonuezhenide, osmanthuside B and osmanthuside D, were isolated from the n-BuOH fraction of Ligustrum japonicum leaves. All six compounds significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.

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