Taxoid from the needles of the Himalayan yew Taxus wallichiana with cytotoxic and immunomodulatory activities

  • Bioorg Med Chem Lett. 2006 May 1;16(9):2446-9. doi: 10.1016/j.bmcl.2006.01.077.
Sunil K Chattopadhyay  1 ,  Anirban Pal ,  Prakas R Maulik ,  Tanpreet Kaur ,  Ankur Garg ,  Suman Preet S Khanuja
Affiliations
  • 1. Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 221005, India. [email protected]
PMID: 16480866 DOI: 10.1016/j.bmcl.2006.01.077
Abstract

The needles of Taxus wallichiana gave a taxoid 1-hydroxy- 2-deacetoxy-5-decinnamoyl-taxinine j, whose structure has been established by spectroscopic data and confirmed by X-ray crystallography. The taxoid possesses significant cytotoxic and immunomodulatory activity.