Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: a new class of cytotoxic compounds

  • Bioorg Med Chem Lett. 2006 Sep 15;16(18):4822-5. doi: 10.1016/j.bmcl.2006.06.074.
Christiana Hadjipavlou  1 ,  Ioannis K Kostakis ,  Nicole Pouli ,  Panagiotis Marakos ,  Harris Pratsinis ,  Dimitris Kletsas
Affiliations
  • 1. Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
PMID: 16824751 DOI: 10.1016/j.bmcl.2006.06.074
Abstract

A series of novel aminosubstituted benzopyranoisoindoles possessing structural analogy to an active nitracrine metabolite are reported. The compounds exhibited interesting cytotoxic activity against a panel of cell lines, which was maximized by the presence of both 1-dialkylaminoethyl and 3-nitro substituents.