Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis

  • J Med Chem. 2006 Jul 27;49(15):4447-50. doi: 10.1021/jm0603724.
Stephen J Baker  1 ,  Yong-Kang Zhang ,  Tsutomu Akama ,  Agnes Lau ,  Huchen Zhou ,  Vincent Hernandez ,  Weimin Mao ,  M R K Alley ,  Virginia Sanders ,  Jacob J Plattner
Affiliations
  • 1. Anacor Pharmaceuticals Inc., 1060 East Meadow Circle, Palo Alto, California 94303, USA. [email protected]
PMID: 16854048 DOI: 10.1021/jm0603724
Abstract

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal Infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.

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