Cytotoxic compounds of Schizolaena hystrix from the Madagascar rainforest

  • Planta Med. 2006 Oct;72(13):1235-8. doi: 10.1055/s-2006-947192.
Brian T Murphy  1 ,  Shugeng Cao ,  Andrew Norris ,  James S Miller ,  Fidisoa Ratovoson ,  Rabodo Andriantsiferana ,  Vincent E Rasamison ,  David G Kingston
Affiliations
  • 1. Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
PMID: 16902871 DOI: 10.1055/s-2006-947192
Abstract

Bioassay-guided fractionation of a crude ethanol extract from a Madagascar collection of Schizolaena hystrix afforded the two new long-chain compounds, 3 S-acetoxyeicosanoic acid ethyl ester ( 1) and 3 S-acetoxydoeicosanoic acid ( 2), and the known long-chain compound 3 S-acetoxyeicosanoic acid ( 3). In addition, the long-chain alcohol 1-hydroxydodecan-2-one ( 7), as well as the new flavonoid schizolaenone C ( 4) and the two known Flavonoids diplacol ( 5) and 3'-prenylnaringenin ( 6) were isolated from a methanol extract of the same plant. Isolation and structure elucidation of the novel compounds and the cytotoxicities of all the isolates are reported.

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