Bioactive guaianolides from siyekucai (Ixeris chinensis)

  • J Nat Prod. 2006 Oct;69(10):1425-8. doi: 10.1021/np068015j.
Shujun Zhang  1 ,  Ming Zhao ,  Liming Bai ,  Toshiaki Hasegawa ,  Jinlan Wang ,  Liyan Wang ,  Hongyan Xue ,  Qigang Deng ,  Fenglan Xing ,  Yuhua Bai ,  Jun-ichi Sakai ,  Jiao Bai ,  Rei Koyanagi ,  Yoshinori Tsukumo ,  Takao Kataoka ,  Kazuo Nagai ,  Katutoshi Hirose ,  Masayoshi Ando
Affiliations
  • 1. Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata, 950-2181, Japan.
PMID: 17067155 DOI: 10.1021/np068015j
Abstract

Two new guaianolides, named chinensiolides D (5) and E (6), were isolated from Ixeris chinensis Nakai, and their structures were determined to be 10alpha-hydroxy-3-oxoguaia-11(13)-eno-12,6alpha-lactone (5) and 10alpha-hydroxy-3beta-O-[2,6-di(p-hydroxyphenylacetyl)-beta-glucopylanosyl]guaia-4(15),11(13)-dieno-12,6alpha-lactone (6). The first isolation of (11S)-10alpha-hydroxy-3-oxoguaia-4-eno-12,6alpha-lactone (4) from natural sources and its characterization are also reported. Chinenciolide E (6) showed significant growth inhibitory activity toward VA-13 malignant lung tumor cells (IC50 = 0.72 microM).